One symbol blind synchronization in SIMO molecular communication systems

Molecular communication offers new possibilities in the micro-and nano-scale application environments. Similar to other communication paradigms, molecular communication also requires clock synchronization between the transmitter and the receiver nanomachine in many time-and control-sensitive applications. This letter presents a novel high-efficiency blind clock synchronization mechanism. Without knowing the channel parameters of the diffusion coefficient and the transmitter-receiver distance, the receiver only requires one symbol to achieve synchronization. The samples are used to estimate the propagation delay by least square method and achieve clock synchronization. Single-input multiple-output (SIMO) diversity design is then proposed to mitigate channel noise and therefore to improve the synchronization accuracy. The simulation results show that the proposed clock synchronization mechanism has a good performance and may help chronopharmaceutical drug delivery applications

Facilitation of Neuropathic Pain by the NPY Y1 Receptor-Expressing Subpopulation of Excitatory Interneurons in the Dorsal Horn

Endogenous neuropeptide Y (NPY) exerts long-lasting spinal inhibitory control of neuropathic pain, but its mechanism of action is complicated by the expression of its receptors at multiple sites in the dorsal horn: NPY Y1 receptors (Y1Rs) on post-synaptic neurons and both Y1Rs and Y2Rs at the central terminals of primary afferents. We found that Y1R-expressing spinal neurons contain multiple markers of excitatory but not inhibitory interneurons in the rat superficial dorsal horn. To test the relevance of this spinal population to the development and/or maintenance of acute and neuropathic pain, we selectively ablated Y1R-expressing interneurons with intrathecal administration of an NPY-conjugated saporin ribosomal neurotoxin that spares the central terminals of primary afferents. NPY-saporin decreased spinal Y1R immunoreactivity but did not change the primary afferent terminal markers isolectin B4 or calcitonin-gene-related peptide immunoreactivity. In the spared nerve injury (SNI) model of neuropathic pain, NPY-saporin decreased mechanical and cold hypersensitivity, but disrupted neither normal mechanical or thermal thresholds, motor coordination, nor locomotor activity. We conclude that Y1R-expressing excitatory dorsal horn interneurons facilitate neuropathic pain hypersensitivity. Furthermore, this neuronal population remains sensitive to intrathecal NPY after nerve injury. This neuroanatomical and behavioral characterization of Y1R-expressing excitatory interneurons provides compelling evidence for the development of spinally-directed Y1R agonists to reduce chronic neuropathic pain

Mulsemedia: State of the art, perspectives, and challenges

Mulsemedia-multiple sensorial media-captures a wide variety of research efforts and applications. This article presents a historic perspective on mulsemedia work and reviews current developments in the area. These take place across the traditional multimedia spectrum-from virtual reality applications to computer games-as well as efforts in the arts, gastronomy, and therapy, to mention a few. We also describe standardization efforts, via the MPEG-V standard, and identify future developments and exciting challenges the community needs to overcome

Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation

The combination of radiation and immunotherapy is currently an exciting avenue of pre-clinical and clinical investigation. The synergy between these two treatment modalities has the potential to expand the role of radiation from a purely local therapy, to a role in advanced and metastatic disease. Tumor regression outside of the irradiated field, known as the abscopal effect, is a recognized phenomenon mediated by lymphocytes and enhanced by checkpoint blockade. In this review, we summarize the known mechanistic data behind the immunostimulatory effects of radiation and how this is enhanced by immunotherapy. We also provide pre-clinical data supporting specific radiation timing and optimal dose/fractionation for induction of a robust anti-tumor immune response with or without checkpoint blockade. Importantly, these data are placed in a larger context of understanding T-cell exhaustion and the impact of immunotherapy on this phenotype. We also include relevant pre-clinical studies done in non-tumor systems. We discuss the published clinical trials and briefly summarize salient case reports evaluating the abscopal effect. Much of the data discussed here remains at the preliminary stage, and a number of interesting avenues of research remain under investigation

Susceptibility of HIV-1 Subtypes B′, CRF07_BC and CRF01_AE that Are Predominantly Circulating in China to HIV-1 Entry Inhibitors

The B', CRF07_BC and CRF01_AE are the predominant HIV-1 subtypes in China. It is essential to determine their baseline susceptibility to HIV entry inhibitors before these drugs are used in China.The baseline susceptibility of 14 representative HIV-1 isolates (5 CRF07_BC, 4 CRF01_AE, and 5 B'), most of which were R5 viruses, obtained from drug-naïve patients to HIV entry inhibitors, including two fusion inhibitors (enfuvirtide and C34), two CCR5 antagonists (maraviroc and TAK779) and one CXCR4 antagonist (AMD3100), were determined by virus inhibition assay. The sequences of their env genes were amplified and analyzed. These isolates possessed similar susceptibility to C34, but they exhibited different sensitivity to enfuvirtide, maraviroc or TAK779. CRF07_BC isolates, which carried polymorphisms of A578T and V583I in the N-terminal heptad repeat and E630Q, E662A, K665S, A667K and S668N in the C-terminal heptad repeat of gp41, were about 5-fold less sensitive than B' and CRF01_AE isolates to enfuvirtide. Subtype B' isolates with a unique polymorphism site of F317W in V3 loop, were about 4- to 5-fold more sensitive than CRF07_BC and CRF01_AE isolates to maraviroc and TAK779. AMD3100 at the concentration as high as 5 µM exhibited no significant inhibitory activity against any of the isolates tested.Our results suggest that there are significant differences in baseline susceptibility to HIV entry inhibitors among the predominant HIV-1 subtypes in China and the differences may partly result from the naturally occurring polymorphisms in these subtypes. This study provides useful information for rational design of optimal therapeutic regimens for HIV-1-infected patients in China

Global air transport complex network : multi-scale analysis

Almost half of the world's population is carried by airlines each year, and understanding this mode of transport is important from economic and scientific perspectives. In recent years, the increasing availability of data has led to complex network and agent interaction models which attempt to gain better understanding of the air transport network and develop forecasts. In this case study paper, we review existing research on two key approaches, namely: (i) a top-down multi-scale network science approach, and (ii) a bottom-up entropy-maximization interaction network approach. Using simple socioeconomic indicators, we were able to construct a very accurate interaction model that can predict traffic volume, and the model can forward estimate the impact of population growth or fuel cost. Using network science approaches, we were able to identify community structures and relate them to economic outputs. We also saw how hubs evolved over time to become more influential. Looking into the future, using random graph theory, it seems that reduced flight cost will lead to increased hub influence. The disseminated knowledge in this case study paper will provide both academics and industry practitioners with steps forward to co-explore the interesting research landscape

Combined gestures and auditory-verbal training for comprehension and production of verbs in deaf children

Objective: An important factor determining the efficacy of speech therapy for children with severe hearing loss is the type and the method of educating children in the use of speech language items. Given the shortage of golden time for language learning, it is necessary to use efficient speech therapy approaches for improving the language of the child. The aim of this study was to investigate the effect of adding gestures to auditory-verbal training (AVT) in speech therapy for children with severe hearing loss. Methods: In this double-blinded clinical trial, 66 children with severe hearing loss were randomly assigned to two groups of 33 subjects. Receptive and expressive language competence for some simple Persian verbs was evaluated by the Newsha test. The AVT was accompanied by gesture for the intervention group and no accompanying gesture for the control group. Simple verbs include fifty early action words such as sit, run, hold, and go. Results: In both the experimental and control groups, a significant difference was observed for receptive language of simple verbs before and after the intervention (P = 0.001, P = 0.045). However, no significant difference was found before the intervention (P = 0.532), there was a significant difference between mean receptive score of the two groups after the intervention (P = 0.032). Conclusion: Adding gestures to AVT significantly changed the mean expressive score in 2-3-year-old children with severe hearing loss. But, both the synthetic approach and the AVT had the same degree of positive effect for education of receptive language of simple verbs for these children. © 2016 Indian Journal of Otology Published by Wolters Kluwer - Medknow